pI: 6.6965 |
Length (AA): 185 |
MW (Da): 20937 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 184 | 2nvu (C) | 6 | 181 | 43.00 | 0 | 1 | 1.61295 | -1.6 |
26 | 142 | 2awf (A) | 1 | 131 | 32.00 | 0 | 1 | 1.12133 | -1.24 |
32 | 167 | 2f4z (A) | 34 | 183 | 31.00 | 0 | 1 | 1.28604 | -1.83 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Trophozoite, Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_128611)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G18600 | ubiquitin-conjugating enzyme family protein |
Arabidopsis thaliana | AT4G36800 | RUB1 conjugating enzyme 1 |
Babesia bovis | BBOV_IV009300 | hypothetical protein |
Candida albicans | CaO19.12866 | potential ubiquitin-like protein-conjugating E2 enzyme similar to S. cerevisiae UBC12 (YLR306W) which acts in Rub1-conjugation, |
Candida albicans | CaO19.5411 | potential ubiquitin-like protein-conjugating E2 enzyme similar to S. cerevisiae UBC12 (YLR306W) which acts in Rub1-conjugation, |
Cryptosporidium hominis | Chro.80032 | ubiquitin-conjugating enzyme e2 |
Cryptosporidium parvum | cgd8_220 | ubiquitin-conjugating enzyme e2 |
Dictyostelium discoideum | DDB_G0281725 | NEDD8-conjugating enzyme |
Drosophila melanogaster | Dmel_CG7375 | Ubiquitin conjugating enzyme 12 |
Echinococcus granulosus | EgrG_000650820 | Ubiquitin carrier protein |
Echinococcus granulosus | EgrG_001154600 | UBiquitin Conjugating enzyme family member |
Echinococcus granulosus | EgrG_002060100 | 3'partial|hypothetical protein |
Entamoeba histolytica | EHI_003010 | ubiquitin-conjugating enzyme family protein |
Echinococcus multilocularis | EmuJ_000351600 | |
Echinococcus multilocularis | EmuJ_001154600 | UBiquitin Conjugating enzyme family member |
Echinococcus multilocularis | EmuJ_000650820 | Ubiquitin carrier protein |
Echinococcus multilocularis | EmuJ_000503220 | protein kinase |
Homo sapiens | ENSG00000130725 | ubiquitin-conjugating enzyme E2M |
Mus musculus | ENSMUSG00000005575 | ubiquitin-conjugating enzyme E2M |
Neospora caninum | NCLIV_019430 | Ubiquitin carrier protein (EC 6.3.2.-), related |
Oryza sativa | 4345411 | Os08g0374100 |
Oryza sativa | 4346713 | Os09g0321900 |
Oryza sativa | 4348232 | Os10g0190000 |
Plasmodium berghei | PBANKA_1458500 | NEDD8-conjugating enzyme UBC12, putative |
Plasmodium falciparum | PF3D7_1245300 | NEDD8-conjugating enzyme UBC12, putative |
Plasmodium knowlesi | PKNH_1465000 | NEDD8-conjugating enzyme UBC12, putative |
Saccharomyces cerevisiae | YLR306W | NEDD8-conjugating protein UBC12 |
Schmidtea mediterranea | mk4.001373.00 | NEDD8-conjugating enzyme Ubc12 |
Toxoplasma gondii | TGME49_280760 | RUB1 conjugating enzyme |
Theileria parva | TP01_0844 | ubiquitin-protein ligase, putative |
Trichomonas vaginalis | TVAG_038060 | ubiquitin-conjugating enzyme E2-25kD, putative |
Trichomonas vaginalis | TVAG_497140 | ubiquitin-conjugating enzyme rad6, putative |
Trichomonas vaginalis | TVAG_074860 | ubiquitin-conjugating enzyme E2-25kD, putative |
Trichomonas vaginalis | TVAG_038730 | nedd8-conjugating enzyme nce2, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_280760 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.